Careful with Propofol Use in Head Trauma! Propofol Infusion Syndrome at Low Dose in an Adolescent

Propofol infusion syndrome.

The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol.l(-1)), rhabdomyolysis, hyperlipidaemia, and enlarged or fatty liver. There is an association between PRIS and propofol infusions at doses higher than 4 mg.kg(-1).h(-1) for greater than 48 h d...

Propofol Infusion Syndrome in Refractory Status Epilepticus

BACKGROUND AND PURPOSE Propofol is used for treating refractory status epilepticus, which has high rate of mortality. Propofol infusion syndrome is a rare but often fatal syndrome, characterized by lactic acidosis, lipidemia, and cardiac failure, associated with propofol infusion over prolonged periods of time. We investigated the clinical factors that characterize propofol infusion syndrome to...

Propofol Infusion Syndrome or Probable Overinterpretation Syndrome?

To the Editor:—It was with great interest that we read the article by Cravens et al. on the incidence of propofol infusion syndrome. This is obviously an important question with significant clinical relevance. However, with all of the inherent limitations of a retrospective study as recognized by the authors, we find the interpretation and conclusion of the authors (“this study provides evidenc...

Propofol infusion syndrome or probable overinterpretation syndrome?

To the Editor:—It was with great interest that we read the article by Cravens et al. on the incidence of propofol infusion syndrome. This is obviously an important question with significant clinical relevance. However, with all of the inherent limitations of a retrospective study as recognized by the authors, we find the interpretation and conclusion of the authors (“this study provides evidenc...

Propofol Infusion Syndrome: A Retrospective Analysis at a Level